REGISTRATION NOW OPEN: “Stem Cells in Neuroscience”, 25th- 27th February, 2026 – Tübingen, Germany

More information: https://stemcelltuebingen.com/

Welcome back! Anabel Dickemann has returned to our lab to begin her PhD after completing her master’s thesis. We are glad to have you back.

Welcome to our newest group member, Benedikt Meyer. Benedikt has been awarded a doctoral scholarship by the Faculty of Medicine at the University of Tübingen to complete his MD thesis in our lab.

Welcome to our newest group member, Moritz Grube. Moritz is studying “Biomedical Science” at the University of Reutlingen and joins the lab for a lab rotation.

Just published: “AAV8 based gene replacement therapy for hereditary spastic paraplegia type 5” in Molecular Therapy – Methods & Clinical Development!

This research brings us one step closer to developing an AAV-based gene therapy for hereditary spastic paraplegia type 5 (SPG5), a debilitating neurological disorder. Our work shows that liver-targeted gene therapy can effectively normalize peripheral oxysterol levels. While we observed promising results in the periphery, the study also highlights the critical need for future strategies to address the central nervous system to fully tackle SPG5. Follow-up studies are already underway.

During the Pint of Science Festival, our master’s student Leelja will present her work on ‘Hermes, the Genetic Messenger: How Viruses Deliver Genes to Cure Diseases’.
Join us at Neckawa, Tübingen on 20th May at 5:30 pm.

Pint of Science Germany organises an international science outreach festival that brings together researchers and the general public in a relaxed atmosphere.

Welcome to our newest group member, Till Stoltenow. Till is studying “Molecular Medicine” at the University of Tübingen and joins the lab for a lab rotation and to complete his bachelor’s thesis.

Almost the entire team (Stefan, Clemens, Jacob, Luisa, Linus, Anabel, Carla, Leelja) will be attending the “iPS Zurich Symposium 2025”. Stefan will talk about our project, “Developing antisense oligonucleotide therapies for SCA3 using iPSC-derived neural models”, while Clemens, Jacob and Linus will present posters about their work.

Stefan and Linus join the “Stem Cells Models of Neurodegeneration (SCMND)” symposium in Edinburgh. Stefan is co-organising this event and Linus is presenting a poster on “Efficient AAV-mediated gene delivery in iPSC-derived neurons”.

Clemens attends the Cure-ND workshop in Paris and presents his work on “Uncovering HSP-SPG4 pathology through axonal proteomics in iPSC-derived cortical neurons”.

We are delighted to welcome Luisa Baraban. Luisa received a prestigious scholarship from the German Academic Scholarship Foundation (Studienstiftung des deutschen Volkes) to pursue her PhD in our lab.

Stefan, Clemens and Anabel attended the Tom Wahlig Symposium and the Treat HSP Meeting in Heidelberg.
Stefan presented an update on “Investigating axon-specific
phenotypes in spastin-deficient iPSC-derived neurons”.

Congratulations to Clemens for winning the “Poster Prize” for his poster on “Uncovering HSP-SPG4 pathology through axonal proteomics in iPSC-derived cortical neurons”.

Welcome to our newest group member, Amelie Leonhardt.
Amelie is studying “Cellular & Molecular Neuroscience” at the Graduate Training Centre of Neuroscience in Tübingen and joins the lab as a research assistant.

Stefan and Jacob attended the International Congress for Ataxia Research (ICAR) 2024 in London and presented our work on “The development of an allele-specific antisense oligonucleotide approach for SCA3”.

Welcome to our newest group member, Carla Kolb.
Carla joins the lab to complete her master’s thesis.

Stefan and Linus attended the ESGCT 2024 conference in Rome.
Linus presented recent results from our project “Developing a screening platform for AAV tropism in iPSC-derived neural cells”.

Welcome to our newest group member, Anabel Dickemann.
Anabel joins us to complete her master’s thesis.

Welcome to our newest group member, Leelja Rößler.
Leelja joins the lab to complete her master’s thesis.

Team event of the group Schöls and Hauser. Played a round of “3D minigolf”.

Welcome to our newest group member, Laura García Manzano. Laura joins the lab to complete her master’s thesis.

Milena, Linus and Clemens attend the Cure-ND workshop “Mechanisms of Neurodegeneration From Bench to Bedside” in Bonn.
Milena has been selected to give a presentation on her research topic “Comparative Omics analyses and disease modeling of hereditary spastic paraplegia type 4 and 31 using CRISPR/Cas9 knockout iPSC-derived cortical neurons”.

Newest publication from the lab: “Generation of homozygous and heterozygous REEP1 knockout induced pluripotent stem cell lines by CRISPR/Cas9 gene editing“.

Jacob, Milena, Clemens and Linus present their work during the poster session at the “Stem Cells in Neuroscience” conference in Tübingen.
Congratulations to Clemens for winning the “Poster Award” for his poster on “Morphological and functional analyses in spastin-deficient iPSC-derived cortical neurons”.

Stefan is co-organizing the “Stem Cells in Neuroscience” conference in Tübingen.

Stefan, Milena, Linus and Clemens attend the Tom Wahlig Symposium and the Treat HSP Meeting in Erlangen.
Stefan will present recent findings from the project “Preclinical development of an AAV-based gene therapy for SPG5”.